risk of prostate cancer strongly influenced by the history of breast and ovarian cancer in the family: Study

risk of prostate cancer strongly influenced by the history of breast and ovarian cancer in the family: Study ;

Prostate cancer risk strongly influenced by breast and ovarian cancer history in family: Study Prostate cancer risk is strongly influenced by the history of breast cancer and ovarian cancer in the family. The findings suggest that men who have a strong family history of breast or ovarian cancer are due to a greater extent detection of prostate cancer, especially if those cancers associated with a BRCA1 or BRCA2 mutation genetic mutation.

The results of the study found that men diagnosed with prostate cancer are four times more likely to have aggressive prostate cancer if they are carriers of the mutation of the BRCA2 gene.

Co-researcher Dr. Srinivas Vourganti said: “They are very high risk of cancer, and we should prepare their programming to be more aggressive in screening versus less aggressive.”

Dr. Brian Halfand, urologic oncologist, said, “I think BRCA is a tool that can begin to use to distinguish who will benefit from earlier treatment and treatments more aggressive type.”

The role of the BRCA genes has been widely underestimated, since the three studies presented at the meeting of the American Urological Association revealed that BRCA mutations are found to play a role in many more cases prostate cancer.

The first study looked at 261 men, all tested positive for BRCA2. These men were also more likely to have the cancer spread through the body and to be diagnosed with late-stage cancer, compared to men without the BRCA2 gene.

The second study observed blood samples from 857 patients with prostate cancer. black patients with prostate cancer were three times more likely to have the BRCA1 or BRCA2 gene, compared with white patients and black patients were more likely to have their cancer spread.

Finally, The third study focused on men who were treated for breast cancer and found men were more than 30 percent higher risk of developing prostate cancer.

Vourganti concluded: “In this era of personalized medicine, there is promise for men who present with BRCA2 are learning that prostate cancer is not a disease Rather, it is many different diseases that need.. be treated personalized and individually. men should talk to their doctors and know that their genes are important. “

hereditary risk of prostate cancer

About five to 10 percent of cases of prostate cancer are derived from connections hereditary . Having a close male relative with prostate cancer – that is, father, brother – .. increases the own risk of developing prostate cancer If two close relatives with prostate cancer after a man’s risk increases fivefold

risk of developing a hereditary prostate cancer is as follows

risk factor The relative risk of prostate cancer
Brother (s) with prostate cancer diagnosed at any age 3.14
Father with prostate cancer diagnosed at any age 2.35
One affected first-degree relative diagnosed at any age 2.48
first-degree relatives affected under 65 2.87
first-degree relatives affected more than 65 1.92
second-degree relatives diagnosed at any age 2.52
Two or first-degree relatives affected more diagnosed any age 4.39

If you are a man and have other male relatives with prostate cancer, you should have yourself screened from the beginning. Moreover, even if you have had female relatives with breast or ovarian cancer, this should still ask you to undergo early detection of prostate cancer to avoid any complications.


Sources:
https://consumer.healthday.com/cancer-information-5/prostate-cancer-news-106/could-breast-cancer-genes-play-role-in-prostate-cancer-too-710812.html
https://www.mskcc.org/cancer-care/risk-assessment-screening/hereditary-genetics/genetic-counseling/inherited-risk-prostate
http://www.cancer.gov/types/prostate/hp/prostate-genetics-pdq


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